Curly hair-acral keratoderma-caries syndrome

What is Curly hair-acral keratoderma-caries syndrome?

Curly hair-acral keratoderma-caries syndrome is an extremely rare ectodermal dysplasia syndrome characterized by premature loss of curly, brittle, dry hair, premature loss of teeth due to caries, nail dystrophy with thickening of the finger- and toe-nails, acral keratoderma and hypohidrosis. Additionally, sparse eyebrows and eyelashes, receding frontal hairline and flattened malar region are associated. The severity of features appears to increase with age.

Other condition names

  • CHAC syndrome


  • Worldwide: <1 in 1,000 000

Age of Onset

  • Adolescent
  • Childhood
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