Acitretin/etretinate embryopathy

What is Acitretin/etretinate embryopathy?

A rare teratogenic disorder due to acitretin or etretinate exposure during the first trimester of pregnancy, carrying a risk of fetal malformations of approximately 20%, including central nervous system, craniofacial, ear, thymic, cardiac and limb anomalies.

Other condition names

  • Fetal acitretin/etretinate syndrome
  • Retinoid embryopathy

Inheritance type

Not applicable


  • Worldwide: <1 in 1,000 000

Age of Onset

  • Antenatal
  • Neonatal
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