Autosomal dominant spastic paraplegia type 9B

What is Autosomal dominant spastic paraplegia type 9B?

A rare predominantly pure hereditary spastic paraplegia characterized by juvenile or adult onset of slowly progressive spastic paraparesis, gait disturbances, and increased tendon reflexes. Additional variable manifestations include pes cavus, dysarthria, sensory impairment, and urinary symptoms. Cognition is normal.

Other condition names

  • AD-SPG9B

Inheritance type

Autosomal dominant


  • Worldwide: <1 in 1,000 000

Age of Onset

  • Adolescent
  • Adult
  • Infancy
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