Cushing syndrome due to macronodular adrenal hyperplasia

What is Cushing syndrome due to macronodular adrenal hyperplasia?

A rare cause of Cushing syndrome (CS) characterized by nodular enlargement of both adrenal glands (multiple nodules above 1 cm in diameter) that produce excess cortisol and features of adrenocorticotropic hormone (ACTH) independent CS.

Other condition names

  • Primary bilateral macronodular adrenal hyperplasia

Inheritance type

Autosomal dominant, Not applicable

Prevalence

  • Europe: <1 in 1,000 000

Age of Onset

  • All ages
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