Enlarged parietal foramina

What is Enlarged parietal foramina?

Enlarged parietal foramina (EPF) is a developmental defect, characterized by variable intramembranous ossification defects of the parietal bones, which is either asymptomatic, symptomatic (headaches, nausea, vomiting, intellectual disability) or associated with other pathologies.

Other condition names

  • Catlin marks
  • Fenestrae parietales symmetricae
  • Foramina parietalia permagna
  • Hereditary cranium bifidum
  • Symmetric parietal foramina

Inheritance type

Autosomal dominant


  • Europe: 1-9 in 100,000
  • Worldwide: 1-9 in 100,000

Age of Onset

  • Antenatal
  • Neonatal
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