Extranodal nasal NK/T cell lymphoma

What is Extranodal nasal NK/T cell lymphoma?

Extranodal nasal NK/T cell lymphoma (NKTCL) is a rare, malignant neoplasm mainly affecting men in the fifth decade of life, that usually arises in the nose, paranasal sinuses, orbits or upper airway, and that can present with a nasal mass, nasal bleeding, nasal obstruction, palate perforation (i.e. midline perforation of the hard palate), and mid-facial and/or upper airway destructive lesions. In advanced disease stages, which are associated with a poor prognosis, NKTCL may disseminate to other organs. A few cases of NKTCL presenting primarily in the lymph nodes have also been described.

Other condition names

  • Angiocentric T-cell lymphoma
  • Lethal midline granuloma
  • NK/T-cell lymphoma
  • Nasal T/natural killer-cell lymphoma

Inheritance type

Multigenic/multifactorial, Not applicable

Age of Onset

  • Adult
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