Familial hyperaldosteronism type I

What is Familial hyperaldosteronism type I?

Familial hyperaldosteronism type I (FH-I) is a rare heritable, glucocorticoid remediable form of primary aldosteronism (PA) characterized by early-onset hypertension, hyperaldosteronism, variable hypokalemia, low plasma renin activity (PRA), and abnormal production of 18-oxocortisol and 18-hydroxycortisol.

Other condition names

  • Dexamethasone-sensitive hypertension
  • FH-I
  • FH1
  • Familial hyperaldosteronism type 1
  • GRA
  • Glucocorticoid-remediable aldosteronism
  • Glucocorticoid-sensitive hypertension

Inheritance type

Autosomal dominant


  • Worldwide: Unknown

Age of Onset

  • Adolescent
  • Adult
  • Childhood
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.