Febrile infection-related epilepsy syndrome

What is Febrile infection-related epilepsy syndrome?

Febrile infection-related epilepsy syndrome (FIRES) describes an explosive-onset, potentially fatal acute epileptic encephalopathy that develops in previously healthy children and adolescents following the onset of a non-specific febrile illness.

Other condition names

  • Acute encephalitis with refractory repetitive partial seizures
  • Acute non-herpetic encephalitis with severe refractory status epilepticus
  • DESC syndrome
  • Devastating epileptic encephalopathy in school-aged children
  • Fever-induced refractory epileptic encephalopathy in school-aged children
  • Idiopathic catastrophic epileptic encephalopathy
  • Severe refractory status epilepticus owing to presumed encephalitis

Inheritance type

Not applicable

Age of Onset

  • All ages
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