Fetal akinesia deformation sequence

What is Fetal akinesia deformation sequence?

The fetal akinesia/hypokinesia sequence (or Pena-Shokeir syndrome type I) is characterized by multiple joint contractures, facial anomalies and pulmonary hypoplasia. Whatever the cause, the common feature of this sequence is decreased foetal activity.

Other condition names

  • Arthrogryposis multiplex congenita-pulmonary hypoplasia syndrome
  • FADS
  • Pena-Shokeir syndrome type 1

Inheritance type

Autosomal recessive

Age of Onset

  • Antenatal
  • Neonatal
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