Holt-Oram syndrome

What is Holt-Oram syndrome?

A genetic syndrome with limb reduction defects characterized by skeletal abnormalities of the upper limbs and mild-to-severe congenital cardiac defects.

Other condition names

  • Atriodigital dysplasia type 1
  • HOS
  • Heart-hand syndrome type 1

Inheritance type

Autosomal dominant

Age of Onset

  • Neonatal
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