Indeterminate cell histiocytosis

What is Indeterminate cell histiocytosis?

A rare neoplastic disease characterized by multiple, and on occasion single, asymptomatic, smooth, red-brown papulonodules located on the face, neck, trunk and/or extremities which present a nonepidermotrophic histiocytic infiltrate with immunohistochemical features of both Langerhans and non-Langerhans cells (i.e. immunopositive for S100 protein and CD1a in the absence of Birbeck granules and langerin expression).

Other condition names

  • Indeterminate dendritic cell neoplasm
  • Indeterminate dendritic cell tumor

Inheritance type

Not applicable

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