Locked-in syndrome

What is Locked-in syndrome?

Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.

Other condition names

  • Cerebromedullospinal disconnection

Inheritance type

Not applicable


  • Worldwide: <1 in 1,000 000

Age of Onset

  • All ages
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