Multiple self-healing squamous epithelioma

What is Multiple self-healing squamous epithelioma?

Multiple self-healing squamous epithelioma (also known as Ferguson-Smith disease (FSD)) is a rare inherited skin cancer syndrome characterized by the development of multiple locally invasive skin tumors resembling keratoacanthomas of the face and limbs which usually heal spontaneously after several months leaving pitted scars.

Other condition names

  • Familial primary self-healing squamous epithelioma of the skin, Ferguson-Smith type
  • Ferguson-Smith disease
  • MSSE
  • Multiple keratoacanthoma, Ferguson-Smith type
  • Self-healing squamous epithelioma type 1

Inheritance type

Autosomal dominant


  • Worldwide: Unknown

Age of Onset

  • Adolescent
  • Adult
  • Childhood
  • Elderly
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