Osteogenesis imperfecta

What is Osteogenesis imperfecta?

Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.

Other condition names

  • Brittle bone disease
  • Glass bone disease
  • Lobstein disease
  • OI
  • Osteopsathyrosis
  • Porak and Durante disease

Inheritance type

Autosomal dominant, Autosomal recessive, X-linked recessive


  • Worldwide: 1-5 in 10,000

Age of Onset

  • All ages
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.