What is Pachydermoperiostosis?

Pachydermoperiostosis (PDP) is a form of primary hypertrophic osteoarthropathy (see this term), a rare hereditary disorder, and is characterized by digital clubbing, pachydermia and subperiosteal new bone formation associated with pain, polyarthritis, cutis verticis gyrata, seborrhea and hyperhidrosis. Three forms have been described: a complete form with pachydermia and periostitis, an incomplete form with evidence of bone abnormalities but lacking pachydermia, and a forme frusta with prominent pachydermia and minimal-to-absent skeletal changes.

Other condition names

  • PDP
  • Touraine-Solente-Gole syndrome

Inheritance type

Autosomal recessive


  • Worldwide: Unknown

Age of Onset

  • Childhood
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