Pituitary gigantism

What is Pituitary gigantism?

A rare endocrine disease characterized by excessively tall stature and rapid growth velocity due to growth hormone excess from a pituitary adenoma/hyperplasia occurring before closure of the epiphyseal growth plates. Additional features may include pubertal delay, visual defects, headache, excessive appetite, hyperhidrosis, menstrual irregularity, prognathism, coarse facial features and large hands/feet.

Other condition names

  • Hypophyseal gigantism
  • Infantile and juvenile forms of acromegaly

Inheritance type

Autosomal dominant, X-linked dominant


  • Worldwide: Unknown

Age of Onset

  • Adolescent
  • Childhood
  • Infancy
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.