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Primary Membranoproliferative Glomerulonephritis

What is Primary Membranoproliferative Glomerulonephritis?

Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes. The primary form affects children and young adults between 8 and 30 years old. The secondary form affects adults over 30 years old.(1,2)

Other condition names

  • Mesangiocapillary glomerulonephritis
  • Primary MPGN
  • Complement 3 glomerulopathy
  • C3 glomerulopathy
  • Dense deposit disease

Inheritance type

Not applicable

Prevalence

  • Europe: 1-5 in 10,000

Age of Onset

  • Adult

  1. Complement 3 Glomerulopathy (C3G). National Kidney Foundation. Available at https://www.kidney.org/atoz/content/complement-3-glomerulopathy-c3g. Accessed 2/3/2023.

  2. Membranoproliferative Glomerulonephritis. Merck Manual. Available athttps://www.merckmanuals.com/professional/genitourinary-disorders/glomerular-disorders/membranoproliferative-glomerulonephritis. Accessed 2/3/2023.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.