Pulmonary non-tuberculous mycobacterial infection (MAC lung disease)

What is Pulmonary non-tuberculous mycobacterial infection (MAC lung disease)?

A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including Mycobacterium avium complex, Mycobacterium kansasii, or Mycobacterium xenopi, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities. Non-tuberculous mycobacteria can cause lung disease, including MAC lung disease.(1)

Other condition names

  • Non-tuberculous mycobacterial lung disease
  • Mycobacterium avium complex
  • MAC lung disease

Inheritance type

Not applicable


  • Europe: 1-9 in 100,000

Age of Onset

  • All ages

(1) MAC Lung Disease. Cleveland Clinic. Available at https://my.clevelandclinic.org/health/diseases/22256-mac-lung-disease. Accessed 11/26/2022.

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