Spinal arteriovenous metameric syndrome

What is Spinal arteriovenous metameric syndrome?

Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution.

Other condition names

  • Cobb syndrome
  • Cutaneomeningospinal angiomatosis
  • SAMS 1-31

Inheritance type

Not applicable


  • Worldwide: <1 in 1,000 000

Age of Onset

  • All ages
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.