Spinocerebellar ataxia type 3
What is Spinocerebellar ataxia type 3?
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common subtype of type 1 autosomal dominant cerebellar ataxia (ADCA type 1; see this term), a neurodegenerative disorder, and is characterized by ataxia, external progressive ophthalmoplegia, and other neurological manifestations.
Other condition names
- Azorean disease of the nervous system
- MJD
- Machado disease
- Machado-Joseph disease
- Nigro-spino-dentatal degeneration with nuclear ophthalmoplegia
- SCA3
Inheritance type
Autosomal dominant
Prevalence
- Worldwide: 1-9 in 100,000
Age of Onset
- Adolescent
- Adult
- Childhood
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.