Splenic marginal zone lymphoma

What is Splenic marginal zone lymphoma?

Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated.

Other condition names

  • SMZL

Inheritance type

Not applicable


  • Europe: 1-9 in 1,000 000

Age of Onset

  • Adult
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