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Wolfram syndrome

What is Wolfram syndrome?

A rare, genetic, endocrine disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs.

Other condition names

  • DIDMOAD syndrome
  • Diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome
  • Diabetes insipidus-diabetes mellitus-optic atrophy-hearing loss syndrome

Inheritance type

Autosomal recessive

Prevalence

  • Worldwide: 1-9 in 1,000 000
  • Europe: 1-9 in 1,000 000

Age of Onset

  • Adolescent
  • Adult
  • Childhood
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.