Acrocardiofacial syndrome

What is Acrocardiofacial syndrome?

A rare genetic disorder characterized by split-hand/split-foot malformation (SHFM), facial anomalies, cleft lip/palate, congenital heart defect (CHD), genital anomalies, and intellectual deficit.

Other condition names

  • ACFS
  • CCGE syndrome
  • Cleft palate-cardiac defect-genital anomalies-ectrodactyly syndrome

Inheritance type

Autosomal recessive


  • Worldwide: <1 in 1,000 000

Age of Onset

  • Antenatal
  • Neonatal
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