Melnick-Needles syndrome

What is Melnick-Needles syndrome?

Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.

Other condition names

  • Melnick-Needles osteodysplasty

Inheritance type

X-linked dominant


  • Worldwide: <1 in 1,000 000

Age of Onset

  • Childhood
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