Familial cold urticaria

What is Familial cold urticaria?

Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

Other condition names

  • FCAS
  • FCU
  • Familial cold autoinflammatory syndrome

Inheritance type

Autosomal dominant


  • Europe: Unknown

Age of Onset

  • Adolescent
  • Childhood
  • Infancy
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