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Nasu-Hakola disease

What is Nasu-Hakola disease?

Nasu-Hakola disease (NHD), also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy characterized by progressive presenile dementia associated with recurrent bone fractures due to polycystic osseous lesions of the lower and upper extremities.

Other condition names

  • NHD
  • PLO-SL
  • PLOSL
  • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy

Inheritance type

Autosomal recessive

Age of Onset

  • Adolescent
  • Adult
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on "https://www.orphadata.com". Data version 1.3.16 / 4.1.7.